Best Acetaminophen of 2025

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 14, 2025

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Acetaminophen is a widely used over-the-counter pain reliever and fever reducer. It is commonly found in various forms such as tablets, capsules, and liquid suspension. It is used to alleviate mild to moderate pain caused by headaches, toothaches, menstrual cramps, arthritis, and other conditions. Acetaminophen is also used to reduce fever and is often recommended for children. It is generally safe when taken as directed, but it is important to follow dosage instructions carefully to avoid overdose and potential liver damage.

At a Glance: Our Top Picks

Amazon Basic Care Extra Strength Pain Relief Caplets Cover#TOP 1
Amazon Basic Care Extra Strength Pain Relief Caplets
ftb score rating icon9.9
Timely - Extra Strength Pain Relief - Acetaminophen Tablet 500 MG - 500 Count Cover#TOP 2
Timely - Extra Strength Pain Relief - Acetaminophen Tablet 500 MG - 500 Count
ftb score rating icon9.8
Amazon Basic Care Rapid Release Pain Relief Caplets Cover#TOP 3
Amazon Basic Care Rapid Release Pain Relief Caplets
ftb score rating icon9.6

Top 10 Acetaminophen

#TOP 1

Amazon Basic Care Extra Strength Pain Relief Caplets

Amazon Basic Care
200 Count
Amazon Basic Care Extra Strength Pain Relief Caplets Cover
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count (Packaging may vary)
ftb score rating icon9.9
FTB Score

Amazon Basic Care Extra Strength Pain Relief Caplets contain Acetaminophen 500mg, which can temporarily relieve minor aches and pains due to various reasons, such as cold, headache, backache, arthritis, toothache, muscular aches, and menstrual cramps, as well as reduce fever. It can be used by adults and children aged 12 and over to relieve pain and fever. Acute pain can be relieved by using this product, which acts as an alarm for sudden pain, such as bee stings or toe stubs.

What We Like
Affordable price
Large quantity (500 count)
Effective pain relief
Easy to swallow
Secure packaging
What We Don't Like
Occasional quality control issues
Uncoated tablets may taste bad

Timely - Extra Strength Pain Relief - Acetaminophen Tablet 500 MG - 500 Count

Timely - Extra Strength Pain Relief - Acetaminophen Tablet 500 MG - 500 Count Cover
Timely Acetaminophen 500mg - 500 Caplets - Extra Strength Pain Relief - Compared to the active ingredient in Extra Strength Tylenol - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis
ftb score rating icon9.8
FTB Score

Timely's Extra Strength Acetaminophen Tablets provide fast-acting pain relief for minor aches and pains, fever, and premenstrual and menstrual cramps. The 500 count bottle ensures long-term relief for the whole family, and the medication is of the highest quality at an affordable price.

What We Like
Cost-effective alternative
Standard 500mg dosage
Quick pain relief
Generics match name brands
Large quantity for price
What We Don't Like
Daily dosage limits
Consult doctor for complications
#TOP 3

Amazon Basic Care Rapid Release Pain Relief Caplets

Amazon Basic Care
W267
Amazon Basic Care Rapid Release Pain Relief Caplets Cover
Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count
ftb score rating icon9.6
FTB Score

Amazon Basic Care Rapid Release Pain Relief Caplets contain 500 mg of acetaminophen which is a fast-acting pain reliever and fever reducer. It is effective in providing temporary relief from headaches, backaches, toothaches, common cold, and menstrual cramps. These extra-strength caplets are gluten-free and come with a child-resistant cap. They are suitable for adults and children above 12 years of age.

What We Like
Economical pain relief solution
Rapid release effectiveness
Easy to swallow
Comparable to brand name
Good quantity for price
What We Don't Like
Red dye may be unnecessary
Not effective for severe pain
#TOP 4

Amazon Basic Care Pain Relief Caplets

Amazon Basic Care
White
100 Count
Amazon Basic Care Pain Relief Caplets Cover
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 100 Count (Packaging may vary)
ftb score rating icon9.5
FTB Score

Amazon Basic Care Pain Relief Caplets are a reliable and effective solution for minor aches and pains. With its active ingredient, acetaminophen 500 mg, it provides fast-acting relief for headaches, backaches, toothaches, and muscular aches. It also helps reduce fever, making it suitable for those suffering from the common cold or flu. These easy-to-swallow caplets are aspirin, caffeine, and gluten-free, making them suitable for adults and children aged 12 years and over. The child-resistant packaging ensures safety. Amazon Basic Care Pain Relief Caplets offer extra strength, making them a convenient choice for those seeking strong and fast-acting pain relief.

What We Like
Cost-effective alternative
Convenient individual packaging
Effective relief for headaches
Same strength as name brands
Highly rated for toothaches
What We Don't Like
Limited frequent use

Amazon Basic Care Acetaminophen 650 mg

Amazon Basic Care
54479
White
Amazon Basic Care Acetaminophen 650 mg Cover
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count
ftb score rating icon9.3
FTB Score

Amazon Acetaminophen Pain Relief offers effective support for those dealing with minor arthritis pain. Each tablet contains 650 mg of acetaminophen, which is designed to relieve pain and reduce fever. This product is particularly useful for alleviating various discomforts, such as muscular aches, backaches, and menstrual cramps. Additionally, the extended-release formula ensures that you experience longer-lasting relief without the worry of taking multiple doses. Plus, it’s gluten-free and aspirin-free, making it a safe choice for many users. The child-resistant cap adds an extra layer of safety for households with children.

What We Like
Effective pain relief
Generous quantity for sharing
Cost-effective generic option
Convenient packaging
Careful dosage consideration
What We Don't Like
High dosage per caplet
Possible interactions with other meds
#TOP 6

Amazon Basic Care Pain Relief Tablets, 100 Count

Amazon Basic Care
White
Amazon Basic Care Pain Relief Tablets, 100 Count Cover
Amazon Basic Care Pain Relief, Acetaminophen Tablets 325 mg, Regular Strength, Pain Reliever and Fever Reducer, 100 Count (Packaging may vary)
ftb score rating icon9.1
FTB Score

Amazon Basic Care Pain Relief Tablets are an effective remedy to temporarily relieve minor aches and pains due to headache, arthritis, and menstrual cramps. It also reduces fever. The active ingredient is acetaminophen 325 mg, a potent pain reliever and fever reducer. It is suitable for both adults and children over six years old. Additionally, it is gluten-free and contains no aspirin.

What We Like
Cost-effective alternative
Effective pain relief
Similar to brand-name
Convenient availability
What We Don't Like
Smaller bottle size than expected
#TOP 7

Timely-Extended Release Pain Relief Acetaminophen Tablet 650MG 400 Count

Timely-Extended Release Pain Relief Acetaminophen Tablet 650MG 400 Count Cover
TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Compared to Tylenol 8 HR Arthritis Pain Active Ingredient - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief
ftb score rating icon9.1
FTB Score

Timely Pain Relief Acetaminophen Tablet 650MG 400 Count is the ideal over-the-counter medication for temporary relief of minor aches and pains, as well as reducing fever. Whether it's a headache, backache, toothache, the common cold, minor arthritis pain, muscular aches, or premenstrual and menstrual cramps, Timely Pain Relief can help. It's also perfect for reducing fever and providing long-term relief for minor arthritis pain. With 400 caplets, it's a great value and an easy way to be pain-free. These caplets are of the highest quality and provide the same efficacy as branded acetaminophen extended release. Keep a bottle in every medicine cabinet and first-aid kit to make sure your family is always prepared for pain relief.

What We Like
Less expensive than name brand
Easy to swallow tablets
Effective pain relief for 6-8 hours
Large container at good price
Competitive pricing with retail stores
What We Don't Like
Slight coating may affect taste
#TOP 8

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets

White
GoodSense Extra Strength Pain Relief, Acetaminophen Caplets Cover
GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count
ftb score rating icon9.0
FTB Score

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count contains Acetaminophen, 500 mg, which temporarily relieves minor aches and pains due to various causes including the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps. It also temporarily reduces fever. It can be used as a pain reliever and fever reducer for adults and children 12 years and over.

What We Like
Cost-effective alternative
Effective pain relief
Easy to swallow
Quick delivery
What We Don't Like
Basic pain reliever

Timely Acetaminophen 500 MG Tablets

Timely Acetaminophen 500 MG Tablets Cover
Timely Acetaminophen 500 MG Tablets 200 Count - Extra Strength Pain Relief - Compared to the active ingredient in Extra Strength Tylenol - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis
ftb score rating icon8.8
FTB Score

Timely Acetaminophen Tablets offer effective relief for various minor aches and pains, including headaches, toothaches, and menstrual cramps. If you're dealing with a fever, this medication can help lower it while easing discomfort. You can trust that these over-the-counter tablets provide the same effectiveness as leading brands, saving you money without sacrificing quality. With 200 tablets in each bottle, you can ensure that your entire family has access to fast-acting pain relief whenever needed.

What We Like
Affordable pricing
Soothe sore back and joints
Good quality and value
Performs as well as brand names
Quick relief from discomfort
What We Don't Like
Uncertain quality perception
#TOP 10

Amazon Basic Care Acetaminophen Extended-Release Tablets

Amazon Basic Care
White
Amazon Basic Care Acetaminophen Extended-Release Tablets Cover
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, 100 Count (Packaging may vary)
ftb score rating icon8.8
FTB Score

Amazon Basic Care Acetaminophen Extended-Release Tablets, also known as Amazon Acetaminophen Tablets, are a safe and effective pain reliever and fever reducer. With its active ingredient, acetaminophen 650 mg, it provides up to 8 hours of relief, helping you get through the day. This medication is great for minor muscle aches and pains, backache, arthritis pain, toothache, premenstrual and menstrual cramps, headache, the common cold, and fever. It's suitable for adults and children 12 years and older. The child-resistant push and turn cap ensures safety. Plus, it's gluten-free and contains no aspirin. Take advantage of the convenience and reliability of Amazon Basic Care Acetaminophen Extended-Release Tablets for all your pain relief needs.

What We Like
Effective pain relief
Affordable price
Comparable to name brands
Large quantity available
What We Don't Like
Excessive quantity for small households
Buying Guide Image

Everything You Need to Know About Acetaminophen

What is Acetaminophen?

Acetaminophen is a common pain reliever and fever reducer. It is often used to treat headaches, muscle aches, and toothaches, as well as to reduce fever. Acetaminophen is the active ingredient in many over-the-counter (OTC) and prescription pain medications, including Tylenol.

How to choose the right Acetaminophen product

When choosing an Acetaminophen product, it's important to consider the strength of the medication and the form it comes in. Most OTC Acetaminophen products come in 325 mg or 500 mg strengths, while prescription Acetaminophen is available in higher strengths.

The form of the medication can also be an important factor. Acetaminophen is available in liquid, tablet, and caplet forms, as well as in combination with other medications, such as cold and flu remedies. It's important to choose the form that is most convenient and easy for you to take.

How much Acetaminophen is safe to take

It's important to follow the dosage instructions on the medication label, as taking too much Acetaminophen can lead to liver damage. The maximum daily dose of Acetaminophen for adults is 4 grams, or 4,000 mg. However, this maximum dose may be lower for individuals with liver disease or who regularly consume alcohol.

It's also important to avoid taking multiple products that contain Acetaminophen at the same time, as this can increase the risk of liver damage. Always read the labels of all medications you are taking, and talk to your doctor or pharmacist if you have any questions or concerns.

When to avoid taking Acetaminophen

Acetaminophen is generally safe for most people when taken as directed. However, there are some situations in which it should be avoided. For example, people who are allergic to Acetaminophen or any of its ingredients should not take it.

Acetaminophen may also interact with certain medications, such as blood thinners and some antidepressants. It's important to talk to your doctor or pharmacist if you are taking any other medications before taking Acetaminophen.

In conclusion

Acetaminophen is a commonly used pain reliever and fever reducer. When choosing an Acetaminophen product, it's important to consider the strength and form of the medication, as well as the maximum daily dose and any potential interactions with other medications. Always follow the dosage instructions on the medication label and talk to your doctor or pharmacist if you have any questions or concerns.

Frequently Asked Questions (FAQs)

1. Is acetaminophen stronger than ibuprofen?

Acetaminophen and ibuprofen have different mechanisms of action. Acetaminophen primarily works in the brain to reduce pain and fever, while ibuprofen works in the brain and the rest of the body, reducing inflammation and swelling at the site of an injury. Therefore, ibuprofen may be more effective for pain caused by inflammation.

2. What are the top 3 side effects of acetaminophen?

The most commonly reported side effects of acetaminophen include nausea, vomiting, and constipation. In some cases, injection site pain and reaction have been reported with the intravenous form of the medication. However, in general, acetaminophen is well-tolerated when used in therapeutic doses.

3. What is acetaminophen used for?

Acetaminophen is commonly used to relieve mild to moderate pain, such as headaches, muscle aches, toothaches, and backaches. It is also used to reduce fever and alleviate symptoms associated with colds, sore throats, menstrual periods, and reactions to vaccinations.

4. Which is better for pain, Tylenol or ibuprofen?

The choice between Tylenol (acetaminophen) and ibuprofen depends on the type of pain. Ibuprofen has anti-inflammatory effects and is more effective for pain caused by inflammation. On the other hand, Tylenol primarily reduces pain and fever, making it suitable for general pain relief. It's best to consult with a healthcare professional for personalized advice.

5. Can I take acetaminophen and ibuprofen together?

Yes, it is generally safe to take acetaminophen and ibuprofen together for extra pain relief, such as after a dental extraction. Combining these medications can provide better pain relief than taking them separately. However, it's important to follow the recommended dosages and consult with a healthcare professional if you have any concerns.

6. Why do hospitals use Tylenol instead of ibuprofen?

Hospitals often prefer to use Tylenol (acetaminophen) as a fever reducer and pain reliever because it has fewer side effects compared to ibuprofen. However, the choice between the two medications may also depend on the specific circumstances and the patient's condition. It's best to follow the guidance of healthcare professionals in a hospital setting.

7. What should I avoid when taking acetaminophen?

When taking acetaminophen, it's recommended to avoid foods high in pectin (including jellies), carbohydrates, and certain cruciferous vegetables (such as broccoli, Brussels sprouts, and cabbage), as they can interfere with the absorption of acetaminophen and reduce its effectiveness.

8. What happens to your body when you take acetaminophen?

Acetaminophen works as a pain reliever and fever reducer. It is believed to elevate the body's pain threshold, making you feel less pain. It also helps lower fever by aiding in the elimination of excess heat from the body. Acetaminophen is commonly used to relieve minor aches and pains and reduce fever.

9. When should I take acetaminophen?

Acetaminophen is commonly used for various conditions, including mild to moderate fever, mild to moderate pain, headaches, muscle aches, and toothaches. It can also be used to alleviate symptoms associated with menstrual periods. It's important to follow the recommended dosage instructions and consult with a healthcare professional if you have any concerns.

Editor's Notes

During our acetaminophen research, we found 26 acetaminophen products and shortlisted 10 quality products. We collected and analyzed 508,642 customer reviews through our big data system to write the acetaminophen list. We found that most customers choose acetaminophen with an average price of $12.69.

The acetaminophen are available for purchase. We have researched hundreds of brands and picked the top brands of acetaminophen, including TIME-CAP LABS, INC., GoodSense. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.

Acetaminophen Comparison Table

#TOP1
Amazon Basic Care Extra Strength Pain Relief Caplets Cover
#TOP2
Timely - Extra Strength Pain Relief - Acetaminophen Tablet 500 MG - 500 Count Cover
#TOP3
Amazon Basic Care Rapid Release Pain Relief Caplets Cover
#TOP4
Amazon Basic Care Pain Relief Caplets Cover
#TOP5
Amazon Basic Care Acetaminophen 650 mg Cover
#TOP6
Amazon Basic Care Pain Relief Tablets, 100 Count Cover
#TOP7
Timely-Extended Release Pain Relief Acetaminophen Tablet 650MG 400 Count Cover
#TOP8
GoodSense Extra Strength Pain Relief, Acetaminophen Caplets Cover
#TOP9
Timely Acetaminophen 500 MG Tablets Cover
#TOP10
Amazon Basic Care Acetaminophen Extended-Release Tablets Cover
BrandAmazon Basic CareTIME-CAP LABS, INC.Amazon Basic CareAmazon Basic CareAmazon Basic CareAmazon Basic CareTIME-CAP LABS, INC.GoodSenseTIME-CAP LABS, INC.Amazon Basic Care
Product BenefitsArthritis Control, Headache Relief, Fever Control, Pain ReliefPain ReliefFever Control, Pain ReliefPain ReliefArthritis Control, Headache Relief, Fever Control, Pain ReliefFever ControlArthritis ControlCold and Flu Control, Arthritis Control, Headache Relief, Fever ControlPain ReliefPain Relief
Item dimensions L x W x H2.2 x 2.2 x 4.5 inches-2.88 x 2.88 x 5.3 inches4.25 x 2.1 x 2.1 inches3.06 x 3.06 x 5.5 inches3.5 x 1.8 x 1.8 inches-3.06 x 3.06 x 5.75 inches3.79 x 2.02 x 3.79 inches2.36 x 2.55 x 4.17 inches
Special Feature-Not required-Fast Acting-Clinically ProvenReduces FeverExtra strengthFast ActingLong-Lasting
Item Weight3.84 ounces500 Milligrams-2.89 ounces--0.64 g11.2 ounces-2.56 ounces
Specific Uses For ProductFeverPain ReliefCold-ArthritisPain ReliefArthritis---
FTB Score
ftb score rating icon9.9
ftb score rating icon9.8
ftb score rating icon9.6
ftb score rating icon9.5
ftb score rating icon9.3
ftb score rating icon9.1
ftb score rating icon9.1
ftb score rating icon9.0
ftb score rating icon8.8
ftb score rating icon8.8
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